2763081-61-2
Chemical Structure
Indoluidin D
- CAS No.: 2763081-61-2
- Formula:C28H28N4O2
- Molecular Weight:452.55
InChIKey: RVAXFCRBPSLXDO-CLJLJLNGSA-N
SMILES: O=C([C@H]1CC2=CC=CC=C2CN1)N[C@@H](C(NC3=CC=C(C=C3)C)=O)CC4=CNC5=CC=CC=C45
Biological Activity: Indoluidin D is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with a human DHODH IC50 of 210 nM. Indoluidin D selectively inhibits human DHODH activity, with induced effects rescuable by orotic acid. Indoluidin D promotes myeloid differentiation and inhibits cancer cell proliferation. Indoluidin D can be used for the research of acute promyelocytic leukemia[1].
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Indoluidin D | Indoluidin D is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with a human DHODH IC50 of 210 nM. Indoluidin D selectively inhibits human DHODH activity, with induced effects rescuable by orotic acid. Indoluidin D promotes myeloid differentiation and inhibits cancer cell proliferation. Indoluidin D can be used for the research of acute promyelocytic leukemia. | |||||||||||||||||||||
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Keywords
